温敏水凝胶在药物缓控释技术中的应用

Applications of thermosensitive hydrogels for controlled and sustained drug release

温敏水凝胶是近几年来发展比较快的一种高分子材料,属于智能水凝胶的一种。虽然迄今为止多数仍停留在实验研究阶段,但可以预见该类水凝胶在医学、农学、生物学等研究领域都有着广阔的应用前景。目前在药物控制释放、组织工程以及生物免疫等多个领域备受关注。本文结合近年来国内外对温敏水凝胶的研究报道,主要介绍了温敏水凝胶的性质及其在药物缓控释中的应用,包括其在药物缓控释制剂中应用的优点、适用的药物类型以及存在的问题等。

Temperature-sensitive（thermosensitive） hydrogel is a kind of composite materials that have been developed rapidly in recent years.They belong to intelligent hydrogels.Although these hydrogels are still in their research phases,they have attracted considerable interest in the fields of medicine,agriculture,and biology.At present,thermosensitive hydrogels have attracted a great attention in various fields,such as controlled drug release,tissue engineering,immunity,and so on.On the basis of pertinent literatures,this review mainly summaries the properties of thermosensitive hydrogels and their applications for controlled and sustained drug release,including the advantages of their applications for controlled and sustained drug release,matched drug types and existing problems.This review could provide theoretical basis for their future researches and applications.