猫运动区青霉素诱发致痫灶手术治疗方法实验研究 第Ⅰ部分:行为学和电生理学变化

The experimental surgical technique research of cats sensorimotor area cortex epileptogenic focus-induced by penicilin.Ⅰ.Observation of electrophysiology and behavior.

目的 :从行为学和电生理学观察上 ,探讨射频或激光技术在治疗致痫灶位于功能区的癫痫的可行性、安全性和有效性。比较致痫灶皮层不同切开形状对手术效果的影响。方法 :建立家猫运动区青霉素局灶性癫痫模型 ,给予不同的手术技术干预 ,通过电生理学和行为学观察 ,比较射频、激光技术和横切刀技术在控制癫痫发作方面的手术效果 ;通过观察术后一周的行为的变化 ,比较三种处理因素在功能保护方面的差异。通过皮层切开不同的形状 ,比较形状对手术效果的影响。结果 :在控制癫痫发作方面 ,射频或激光技术与传统的横切刀技术相比 ,统计学比较无显著性差异 (P >0 0 5 ) ;在功能保护方面 ,三者也无差异 ;皮层切开的形状对癫痫发作的控制 ,统计学比较无显著性差异 (P >0 0 5 )。结论 :行为学和电生理学观察 ,射频和激光技术在治疗功能区癫痫是可行的 ,其手术效果是安全。

Objective:Disccuss the feasibility,safty,and effectiveness of radiofrequency and laser techniques in treating the epileptogenic focus located in functional area,and the different cortex incision shape is compared in seizure control,by the observation of behavior and eletrophysiology.Method:Firstly,establish the cats sensorimotor cortex focal epilepy model-induced by penicillin,and three kinds of techniques is applied in the animals epilepsy model.The radiofrequency,laser and transector techniques are compared in seizure control and functional preservation by observation one-week behavior and EEG.Result:In seizure control and functional preservation,three kinds of techniques is similar without prominent differency in statistics(P>0.05).The cortex incision shape doesnt have affect on seizure control without differency in statistics(P>0.05).Conclusion:The radiofrequency and laser techniques are able to be applied to treat the epileptogenic focus located in functional area cortex.