摘要
目的探讨烫伤大鼠补锌后金属硫蛋白(Metallothionein MT)的变化。方法观察了SD 大鼠在缺锌状态下烫伤,进食缺锌(4μg/g)、低锌(10μg/g)、高锌(80μg/g)三种含锌量不同饲料,其血清锌、肝脏锌、肝 MT 的变化。结果血清锌下降,肝脏锌、肝脏 MT 升高,含锌量越大,血清锌、肝脏锌、肝脏 MT 越高。高锌组最明显,肝脏 MT 高出低锌组9倍(P<0.01)。相关分析表明,肝脏锌与肝 MT 的变化呈正相关(r=0.85,P<0.01)。结论烫伤后血清锌下降肝脏锌增加,与肝脏 MT 合成增多有关;锌是 MT 的诱导剂,促进 MT 的合成。
Objective To investigate the changes in liver metallothionein (MT) in scalded rats. Methods The scalded rats in deficient zinc condition were fed with diets containing zinc 4μg/g、10μg/g、 and 80μg/g respectively.The changes in serum zinc,liver zinc and liver MT were observed.Results The serum zinc decreased,liver zinc and MT increased.The higher diet zinc levels were,The higher serum zinc,liver zinc and MT became.The correlation analysis showed that the changes between liver zinc level and liver MT was positive relationship(r= 0.85,P<0.01).Conclusion Serum zinc decrease, liver zinc increase after burn.This is connect with increment of MT synthesis in liver,zinc is inducer to MT.It can improve synthesis of liver MT.
基金
"八五"军队医药卫生科研基金资助项目(编号:91Z009-009)
