冠心病患者对氧磷酶水平变化及其与冠脉病变的相关性研究

Study of correlationship between paraoxonase and coronary lesions on coronary heart disease patients

目的探讨对氧磷酶(PON)在冠心病(CHD)患者中的临床意义。方法经选择性冠状动脉造影结果将300例入院患者分为冠心病组240例和对照组60例。冠心病组根据临床诊断分为稳定型心绞痛(SAP)组60例和急性冠脉综合征(ACS)组180例;根据冠脉病变类型分为A型病变、B型病变和C型病变组,血清PON水平通过乙酸苯酯法测定。结果 PON水平明显低于对照组,PON水平明显低于SAP组,随冠状动脉病变类型和冠状动脉病变程度的加重,PON水平逐渐下降。结论 PON是反映冠状动脉粥样硬化斑块局部炎症的较好指标,是决定斑块稳定性的机制之一。

Objective To investigate the clinical significance of paraoxonase（PON1） in coronary heart disease（CHD）.Methods We choosed 300 hospitalized coronary heart disease patients according to the results of selective coronaryangiography.Then,we divided them into coronary heart disease group（n=240）and control group（n=60）.Coronary heart disease group were divided into stable angina pectoris（SAP）group（n=60）and acute coronary syndrome（ACS） group（n=180） according to clinical diagnosis.Coronary heart disease group were divided into A group,B group and C group according to type of coronary artery disease＇s pathological changes.Meanwhile,the PON concentration level was detected by pheny acetate method.Results PON level was significantly lower than the control group.In ACS group,the PON level significantly was lower than that of the SAP group,When the CHD is more severer the level of PON will be more lower.with coronary artery disease type and the severity of coronary artery disease,while the PON level gradually decreased.Conclusions PON would be better indicators to reflect the local inflammation of atherosclerotic plaque,so that,it can be the key mechanism of atherosclerotic plaque＇s stability.