奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的疗效观察

Effect observation of Ozagrel combined Shuxuening injection in treatment of acute cerebral infarction

目的观察奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的临床疗效。方法将符合病例入选标准的60例患者随机分为观察组、对照组。2组均给予阿司匹林、舒血宁注射液等常规治疗,观察组同时加用奥扎格雷钠80mg静脉滴注,每日2次。2组均以连续治疗2周为1个疗程,治疗1个疗程后观察临床疗效。结果观察组痊愈率为36.67%,对照组痊愈率为20.00%,2组相比差异有统计学意义(P<0.05);观察组总有效率为76.67%,对照组总有效率为66.67%,2组相比差异有统计学意义(P<0.05)。全血高、中、低切黏度,血浆黏度,红细胞压积,血小板最大聚集率2组治疗前后组内相比差异有统计学意义(P<0.05);2组治疗后组间相比差异亦有统计学意义(P<0.05)。2组治疗前神经功能缺损程度评分组间相比差异无统计学意义(P>0.05);治疗后第7d、第14d与治疗前相比差异有统计学意义(P<0.05);治疗后第14d 2组组间相比差异有计学意义(P<0.05)。结论奥扎格雷钠联合舒血宁注射液治疗急性脑梗死临床疗效显著,可改善血液流变学指标,改善神经缺损。

Objective To observe the clinical effect of ozagrel injection and Shuxuening injection in treating acute cerebral infarction.Methods The cases selected will comply with the standard 60 patients were randomly divided into 2 groups observation group and control group.2 groups were given aspirin,Shuxuening injection and other conventional treatment,the observation group were added ozagrel injection 80mg intravenously 2 times a day.Group 2 are continuous treatment for 2 weeks as a course of treatment after a course of clinical efficacy was observed.Results The cure rate was 36.67%,20.00% cure rate in control group,2 group was significantly different（P0.05）;Observation group the total effective rate was 76.67%,the control group,the total effective rate was 66.67%,2 groups were significantly different.Whole blood of high,medium and low shear viscosity,plasma viscosity,hematocrit,platelet aggregation in group 2 compared before and after treatment was significantly different（P0.05）;2 group after treatment,differences between the two groups are compared statistically significant（P0.05）.2 groups before treatment,neurological deficit scores between groups was no significant difference（P0.05）;7 days after treatment,the first 14 days compared with before treatment was significantly different（P0.05）;Treatment group 2 after 14 days compared to the difference between the groups total significance（P0.05）.Conclusions The combined ozagrel injection and Shuxuening injection in treating acute cerebral infarction have a significant clinical effect,can improve hemorheology and mentally defect.