口腔白斑及口腔鳞状细胞癌中Livin和Caspase-3蛋白表达研究

Expression of Livin and Caspase-3 protein in oral leukoplakia and oral squamous cell carcinoma

目的研究Livin和caspase-3蛋白在正常口腔黏膜、口腔白斑和口腔鳞状细胞癌中的表达。方法免疫组化SP法检测正常口腔黏膜、口腔白斑和口腔鳞状细胞癌中Livin和caspase-3蛋白的表达。结果 Livin蛋白在正常口腔黏膜、口腔白斑和口腔鳞状细胞癌中的表达率为20%、33.33%和86.49%;caspase-3蛋白在正常口腔黏膜、口腔白斑和口腔鳞状细胞癌中的表达率为100%、83.33%和43.24%;caspase-3蛋白表达与livin蛋白表达有明显的负相关关系(P<0.05)。结论 Caspase-3的缺失和Livin的高表达与口腔白斑癌变的发生发展相关,两者联合检测有助于早期识别口腔白斑癌变。

Objective Study the expressions of Livin and caspase-3 proteins in the normal oral mucosa,oral leukoplakia and oral squamous cell carcinoma.Methods Expression of Livin and caspase-3 protein were detected by immunohistochemistry S-P methods in the normal oral mucosa,oral leukoplakia and oral squamous cell carcinoma.Results Positive rates of Livin protein in the normal oral mucosa,oral leukoplakia and oral squamous cell carcinoma were 20.00%,33.33% and 86.49%;Positive rates of caspase-3 protein in the normal oral mucosa,oral leukoplakia and oral squamous cell carcinoma were 100%,83.33% and 43.24%.The expression of caspase-3 protein was obviously negative related to livin protein（P0.05）.Conclusions Deletion of Caspase-3 protein and abnormal expression of survivin protein were related to OLK cancer,and early detection of them can help to identify OLK cancer.