肝癌早期诊断标志物

Tumor markers for early diagnosis of human hepatocellular carcinoma

肝癌（HCC）的早期诊断对其预后非常关键,筛选出能够帮助肝癌早期诊断的肿瘤标志物成为迫切需要.研究表明包括人宫颈癌基因、γ-谷氨酰转移酶mRNA、人端粒酶反转录酶mRNA、磷脂酰肌醇蛋白聚糖-3、高尔基体蛋白73、血管内皮生长因子、转化生长因子β1等在内的一些基因及转录产物和蛋白质可以作为肝癌早期诊断的标志物.

Early detection of HCC is critical for a good prognosis. Therefore, the development of tumor markers that can detect HCC at even earlier stages is urgent. Recent researches show that the human cervical cancer oncogene, gamma-glutamyl transferase mRNA, human telomerase reverse transcriptase mRNA, the proteins such as glypican-3, golgi protein 73, vascular endothelial growth factor and transforming growth factor-β1 could serve as markers for early detection of HCC.