匹多莫德治疗麻疹的临床疗效及对T淋巴细胞亚群的影响

Clinical effectiveness of Pidotimod in the treatment of measles and effect on the T achroacyte subgroup

目的:探讨匹多莫德治疗麻疹的临床疗效及对T淋巴细胞亚群的影响。方法:选择2008年6月～2010年5月住院诊治的麻疹患儿76例,随机将其分为观察组和对照组各38例。对照组予以抗病毒、预防感染、对症处理等常规治疗;观察组在对照组治疗基础上加用匹多莫德分散片0.4 g口服,连续服用1个月。结果:观察组总有效率为92.11%,明显优于对照组73.68%,两组比较差异有统计学意义(χ2=4.547,P<0.05);观察组在退热时间、咳嗽缓解时间及肺部啰音减少或消失时间三项指标与对照组比较差异均有统计学意义(P<0.05或P<0.01);治疗后观察组CD3+(57.64±2.63)%和CD4+(34.65±2.44)%较对照组[(56.45±2.36)%、(33.52±2.35)%]明显升高,观察组患儿CD8+(23.86±2.17)%较对照组(24.95±2.14)%明显降低,两组三项指标比较差异有统计学意义(t CD3+=2.076、t CD4+=2.056,tCD8+=2.205,均P<0.05)。结论:匹多莫德在辅助麻疹治疗过程中疗效肯定,具有恢复被抑制的免疫能力,可提高机体细胞免疫的功能,值得临床选用。

Objective： To study the clinical effectiveness of Pidotimod in the treatment of measles and its effect on the T achroacyte subgroup.Methods： 76 patients with measles treated in hospital from June 2008 to May 2010 were selected as the research object,and were randomly divided into the observation group and the control group,each 38 cases.The control group was given the routine therapy such as anti-viral,infection prevention and symptomatic treatment etc;the observation group,in the basis of the control group therapy,adding 0.4 g Pidotimod scattered slices for oral administration,continue for one month.Results： the total effective rate of the observation group was 92.11%,better than the 73.68% of the control group.Difference of two groups was statistically significant（P0.05）.The observation group in anti-febrile time,cough alleviate time and lungs sound reduction or disappearing time,the three indexes compared with the control group difference had statistically significant（P0.05 or P0.01）;After treatment,CD3＋ and CD4＋ of the observation group were significantly higher than those of the control group,and the CD8＋ of the observation group decreases obviously than that of the control group,there was significant difference in three indexes of two groups（P0.05）.Conclusion： efficacy of the Pidotimod in the measles auxiliary treatment shall be ensured,which can recover the immune ability suppressed and improve the body cellular immune function,and is deserved to the clinical selection.