苍葛止泻灵诱生鼠干扰素的实验研究

Experimental Studies on Cang Ge Zhixieling in Inducing Interferon in Mice

目的:观察苍葛止泻灵在小鼠体内诱生干扰素的作用。方法:微量细胞病变抑制法(CPE)测定干扰素效价。结果:苍葛止泻灵高、中剂量组具有明显诱生鼠干扰素的作用,与对照组比较P<0.01,其中腹腔注射组高于灌胃组。诱生时间24h达高峰,其效价为(256±24.8)U/ml。结论:苍葛止泻灵具有诱生和促诱生鼠干扰素的作用。

OBJECTIVE: To observe the function of Cang ( Atractylodes Lancea )and Ge( Pueraria Lobata )Zhixieling in inducing interferon in mice.METHOD:CPE method was used to determine interferon titer.RESULT:Interferon in mice can be induced by Cang Ge Zhixieling after being taken either large or moderate in dosage by them with P <0.01 in comparison with the control group.Furthermore,abdominal cavity injection group is more capable in inducing the interferon than the stomach perfusion group.Fastigium with a titer of (256±24.8)U/ml ws reached 24 h after inducement.CONCLUSION:Cang Ge Zhixieling has the effect in inducing interferon in mice.