老年慢性气管炎患者治疗前后血清SOD IL-6 IL-8 IL-10和TNF-α水平检测的临床意义

Clinical significance of measurement of serum SOD,IL-6,IL8,IL-10 and TNF-α levels before and after treatment in patients with old chronic bronchitis

目的探讨老年慢性支气管炎患者治疗前后血清SOD、IL-6、IL-8、IL-10和TNF-α水平的变化及临床意义。方法应用放射免疫分析对36例老年慢性气管炎患者进行了治疗前后血清SOD、IL-6、IL-8、IL-10和TNF-α水平检测,并与35名正常健康人作比较。结果治疗前,患者血清SOD、IL-10水平非常显著地低于正常人组(P<0.01),而血清IL-6、IL-8、TNF-α水平又非常显著地高于正常人组(P<0.01)。经治疗1个月后,血清SOD水平与正常人比较差异无显著性(P>0.05),而IL-6、IL-8、IL-10和TNF-α与正常人比较仍有显著性差异(P<0.05)。血清SOD水平与IL-6、IL8和TNF-α水平呈负相关(r=-0.4956;-0.5982;-0.6014;P<0.01)。与IL-10水平呈正相关(r=0.4182;P<0.01)。结论检测老年慢性气管炎患者血清SOD、IL-6、IL-8、IL-10和TNF-α水平的变化对了解疾病的病理机制和病情评估均有重要的临床价值。

Objective To explore the significance of changes of serum SOD,IL-6,IL-8,IL-10 and TNF-α levels before and after treatment in patients with old chronic bronchitis.Methods Serum SOD,IL-6,IL-8,IL-10 and TNF-α levels were measured with RIA in 36 patients both before and after treatment in patients with old chronic bronchitis as well as in 35 controls.Results Before treatment serum SOD,IL-10 levels were significantly lower than those in the controls（P0.01）,but serum IL-6,IL-8,IL-10 and TNF-α levels were significantly higher than those in the controls（P0.01）.One month after treatment,serum SOD levels were not significantly different from the controls（P0.05） while serum IL-6,IL-8,IL-10 and TNF-α levels remained significantly higher（P0.05）.Serum SOD levels were negatively correlated with IL-6,IL-8,IL-10 and TNF-α（r=-0.4956,-0.5982;-0.6014.P0.01）,whereas SOD levels were positively correlated with IL-10 levels（r=0.4182,P0.01）.Conclusion Changes of serum SOD,IL-6,IL-8,IL-10 and TNF-α after treatment were consistent are with the resolution of inflammatory condition in patients with old chronic bronchitis.