复方卡尼汀注射液治疗病毒性肝炎

Effect of compound carnitine injection in treating viral hepatitis

目的 :观察复方卡尼汀注射液治疗病毒性肝炎的疗效。方法 :对照组 30例 ,男性 2 4例 ,女性 6例 ,年龄 ( 41±s 11)a ,常规保肝治疗 (菌栀黄 2 0mL ,iv ,gtt ,qd ,维生素C 2 .0g及维生素B60 .2g ,iv ,gtt ,qd等 ) ,疗程 4wk。治疗组 30例 ,男性2 4例 ,女性 6例 ,年龄 ( 45± 10 )a ,常规保肝治疗加用复方卡尼汀注射液 2支 ,iv ,gtt ,qd ,疗程 4wk。结果 :2组临床疗效比较差别有显著意义 (P<0 .0 5 ) ;2组丙氨酸转氨酶 (ALT)治疗前后比较差别均有显著意义 (P <0 .0 5 ) ,血清总胆红素 (TB)治疗前后比较 ,治疗组差别有显著意义 (P <0 .0 5 ) ,对照组差别无显著意义 (P >0 .0 5 ) ;治疗后 2组组间比较ALT差别无显著意义 (P >0 .0 5 ) ,TB差别有非常显著意义 (P <0 .0 1)。 2组均无明显副作用。结论 :复方卡尼汀注射液是一种有效安全的保肝药 。

AIM: To study the effect of compound carnitine injection on viral hepatitis. METHODS: The control group [M 24, F 6; age (41±s 11) a] was given conventional therapy (Yinzhihuang 20 mL iv, gtt, qd, vitamin C 2.0 g iv, gtt, qd and vitamin B 6 0.2 g iv, gtt, qd) for 4 wk. The treatment group [M 24, F 6; age (45±10) a] was given compound carnitine injection 2 vials, iv gtt, qd, for 4 wk in addition to conventional therapy. RESULTS : The symptoms and signs in the treatment group were improved in comparison with the control group ( P < 0.05). The ALT in two groups were all improved (P<0.05) after the treatment. The TB after the treatment were improved (P<0.05) in the treatment group, but not (P>0.05) in the control group. After the treatment the ALT tended to improve (P>0.05) in the treatment group in comparison with the control group. After the treatment the serum bilirubin were improved (P<0.01) in the treatment group in comparison with the control group. CONCLUSION: Compound carnitine injection is an effective and safe drug in treating viral hepatitis, especially in reducing the serum bilirubin.