摘要
目的 :研究贝那普利对高血压病人尿微量清蛋白及肾功能的作用。方法 :42例高血压病人 [男性 2 9例 ,女性 13例 ;年龄 ( 49±s 4)a ;病程 ( 3.8±0 .7)a]应用贝那普利 10mg ,po ,qd× 6wk ;治疗前后检测比较病人的血压、尿微量清蛋白、肾功能等各项指标。结果 :贝那普利治疗 6wk后 ,病人血压及尿微量清蛋白降低有非常显著意义 (P <0 .0 1) ;血浆肾素活性增加有非常显著意义 (P <0 .0 1) ;其他肾功能指标无明显影响。结论 :贝那普利可在有效降低血压的同时 ,对尿微量清蛋白有减低作用 。
AIM:To observe the effects benazepril on blood pressure, urinary excretion of albumin and renal function. METHODS: Forty_two patients [M 29, F 13; age (49±s 4) a; course of disease (3.8±0.7) a] with essential hypertension received benazepril 10 mg, po, qd for 6 wk. Their blood pressure, microalbuminuria and renal function were re_examined. RESULTS: The blood pressure and microalbuminuria decreased(P<0.01). Plasma renin activity increased(P<0.01). But other renal functions were no significant changes. CONCLUSION:This study showed that benazepril was able to reduce urinary excretion of albumin and blood pressure in patients with essential hypertension and benazepril has protection effects on renal function.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第5期305-306,共2页
Chinese Journal of New Drugs and Clinical Remedies
关键词
贝那普利
高血压
清蛋白尿
肾功能试验
benazepril
hypertension
albuminuria
kidney function tests