草苁蓉化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTES OF BOSCHNIAKIA ROSSICA FEDTSCH. ET FLEROV

目的：研究我国民间草药草苁蓉［ Ｂｏｓｃｈｎｉａｋｉａ ｒｏｓｓｉｃａ （ Ｃｈａｍ ．ｅｔ Ｓｃｈｌｔｄｌ） Ｆｅｄｔｓｃｈ ．ｅｔ Ｆｌｅｒｏｖ ．］ 的化学成分。方法：草苁蓉全草醇提取物的乙酸乙酯部位经硅胶柱色谱和制备薄层分离，分得８ 个化合物。通过波谱和化学方法鉴定了它们的结构。结果：８ 个化合物的结构分别鉴定为４ ，５ ，６三羟基噢酮（１） 、β谷甾醇（２） 、β谷甾醇３ Ｏβ Ｄ葡糖苷（３） 、７去氧８表马钱子酸（４） 、没食子酸（５） 、肉桂酸（６） 、咖啡酸（７） 和草苁蓉纳拉苷（８） 。结论：４ ，５ ，６三羟基噢酮（１） 为新的噢酮化合物，４ 个已知化合物：７去氧８表马钱子酸（４） 、没食子酸（５） 、肉桂酸（６） 、咖啡酸（７） 为首次从草苁蓉中分得。

AIM: To investigate the chemical constituents of Boschniakia rossica (Cham. et Schltdl) Fedtsch. et Flerov. METHODS: The alcohol extracts of the whole plants of B.rossica was extracted with petroleum ether and EtOAc, respectively. Eight compounds were isolated from the EtOAc part by using repeated silica gel column chromatography and preparative TLC, and their structures were determined by chemical conversion and spectral methods. RESULTS: The eight compounds were identified as 4,5,6 trihydroxy aurone (1), β sitosterol (2), β sitosterol 3 O β D glucopyranoside (3), 7 deoxy 8 epiloganic acid (4), gallic acid (5), cinnamic acid (6), caffeic acid (7) and baschnaloside (8), respectively. CONCLUSION: 4,5,6 Trihydroxy aurone (1) was a new compound, compounds (4), (5), (6) and (7) were isolated from this plant for the first time.