期刊文献+

舒芬太尼对乳腺癌改良根治术应用快通道麻醉的影响 被引量:3

下载PDF
导出
摘要 目的观察舒芬太尼诱导对乳腺癌改良根治术应用快通道麻醉的影响。方法将90例择期行乳腺癌改良根治术患者随机分为舒芬太尼组、芬太尼组、瑞芬太尼组各30例。术中以七氟烷、丙泊酚及瑞芬太尼术复合维持麻醉,维持脑电双频指数(B IS)在50±10。观察诱导前(T0)、诱导插管后即刻(T1)、插管后5 m in(T2)、切皮后5 m in(T3)、手术结束时(T4)、拔管后5 m in(T5)的平均动脉压(MAP)、心率(HR);记录苏醒期躁动、拔管时间、拔管后在麻醉后监护室(PACU)停留时间、芬太尼处理例数;视觉模拟(VAS)评分记录拔管后10 m in(V1)、出PACU时(V2)、术后6 h(V3)、术后24 h(V4)、24 h内VAS评分最高值(V5);记录术中瑞芬太尼用量及24 h术后镇痛药物用量。结果三组术中MAP及HR均平稳,拔管时间组间比较差异无统计学意义;舒芬太尼组在苏醒期躁动、拔管后在PACU停留时间及芬太尼处理例数方面均优于芬太尼组和瑞芬太尼组;VAS评分在拔管后10 m in及24 h内VAS评分最高值等方面舒芬太尼组优于芬太尼组和瑞芬太尼组;舒芬太尼组术中瑞芬太尼用量及24 h术后镇痛药物用量少于芬太尼组和瑞芬太尼组。结论舒芬太尼诱导在乳腺癌根治术快通道麻醉中不影响麻醉效果,可抑制瑞芬太尼的痛觉过敏现象,并能减少短期内术后疼痛的评分。
出处 《山东医药》 CAS 北大核心 2011年第15期69-71,共3页 Shandong Medical Journal
  • 相关文献

参考文献8

  • 1Thomson IR, Harding G, Hudson RJ. A comparison of fentanyl and sufentanil in patients undergoing coronary artery bypass graft [ J ]. J.Cardiothorac Vase Anesth,2000,14(6) :652-656.
  • 2van Vlymen JM,White PF. Fast-track concept for ambulatory anesthesia[ J]. Curt Opin Anaesthesiol, 1998,11 (6) :607-613.
  • 3金昔陆,池志强.μ阿片受体激动剂舒芬太尼的药理作用和应用[J].中国现代应用药学,1999,16(1):1-5. 被引量:244
  • 4Angst MS, Koppert W, Pahl I, et al. Short-term infusion of the muopioid agonist remifentanil in humans causes hyperalgesia during with drawal[J]. Pain,2003,106(1-2) :49-57.
  • 5Guignard B, Bossard AE, Coste C, et al. Acute oPioid tolerance :intr aoperative remifentanil increases postoperative pain and morphine requirement[ J]. Anesthesiology,2000,93 (2) :409-417.
  • 6丛露,王珊娟,杭燕南.芬太尼、舒芬太尼、瑞芬太尼对呼吸功能的影响[J].实用疼痛学杂志,2007,3(5):379-383. 被引量:95
  • 7汪芳俊,万勇,刘洋,涂发平.雷米芬太尼导致术后痛觉过敏的剂量依赖关系[J].临床麻醉学杂志,2009,25(11):937-939. 被引量:30
  • 8Borgland SL. Acute opioid receptor desensitization and tolerance:is there a link [ J]. Clin Exp Phannacol Physiol, 2001,28 ( 3 ) : 147- 154.

二级参考文献36

  • 1徐志荣,方能新,钱梅,张健,曾一平.雷米芬太尼复合丙泊酚用于无痛人流的临床观察[J].临床麻醉学杂志,2005,21(3):202-203. 被引量:49
  • 2Vinik HR, Kissin I. Rapid development of tolerance to analgesia during remifentanil infusion in humans. Anesth Analg, 1998, 86:1307-1311.
  • 3Angst MS, Koppert W, Pahl I, et al. Short-term infusion of the mu opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain, 2003, 106: 49-57.
  • 4Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology, 2000, 93: 409- 417.
  • 5Trafton JA, Abbadie C, Marek K, et al. Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J Neurosci, 2000, 20: 8578-8584.
  • 6Borgland SL. Acute opioid receptor desensitization and tolerance: is there a link? Clin Exp Pharmacol Physiol, 2001, 28: 147-154.
  • 7Gardell LR, Wang R, Burgess SE, et al. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci, 2002, 22:6747-6755.
  • 8Laulin JP, Maurette P, Corcuff JB, et al. The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg, 2002, 94: 1263-1269.
  • 9Joly V, Richebe P, Guignard B, et al. Remifentanil-indueed postoperative hyperalgesia and its prevention with small dose ketamine. Anesthesiology, 2005, 103: 147-155.
  • 10[1]Matthes HW,Smadja C,Valverde O,et al.Activity of the delta-opioid receptor is partially reduced,whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.J Neurosci,1998,18:7285-7295.

共引文献362

同被引文献27

引证文献3

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部