在猫取消睡眠后莫达非尼和安非他明对睡眠觉醒周期的作用(英文)

Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats

目的:对猫正常条件下和取消睡眠后莫达非尼和安非他明对睡眠觉醒周期以及脑皮质电波的作用进行测定。方法:应用水池平台技术取消猫的睡眠。在取消睡眠前或取消睡眠后分别给于猫口服莫达非尼5mg·kg^(-1)、安非他明1mg·kg^(-1)。结果:莫达非尼在取消睡眠前或取消睡眠后引起的觉醒作用相同(8-9h),并且不增加后续睡眠的反弹。相反安非他明在取消睡眠后的觉醒作用持续时间(8h)少于正常条件下引起的觉醒时间(10-12h),引起慢波睡眠和异相睡眠的明显反弹。结论:上述结果提示莫达非尼有效地拮抗嗜睡状态和过度睡眠症状而不引起后续睡眠时间的增加。

AIM: The effects of modafinil and amphetamine on sleep-wake cycle and cortical power spectrum were assessed in the cats before and after sleep deprivation. METHODS: The sleep deprivation in the cats was used with the water tank technique. Cats were administrated with modafinil (5 mg·kg-1 po ) or amphetamine (1 mg·kg-1) before and after sleep deprivation. RESULTS: The waking effect of 8 -10 h induced by modafinil before and after sleep deprivation was similar and was not followed by an increase in sleep rebound. On the contrary, the arousal effect about 8 h evoked by amphetamine after sleep deprivation was less lasting than that of 10 -12 h observed in normal conditions and followed by an amplified rebound in both deep slow wave sleep and paradoxical sleep. CONCLUSION: These results suggest the efficiency of modafinil against somnolence and hypersomnia without increasing subsequent sleep.