前列腺素E_1联合脱氧核苷酸钠治疗儿童急性肾损伤疗效观察

Effects of prostaglandin E1 combined with deoxyribonucleotide natrium in the treatment of children with acute kidney injury

目的探讨前列腺素E1联合脱氧核苷酸钠治疗儿童急性肾损伤(AKI)的疗效。方法实验分组:①对照组(20例,常规治疗);②前列腺素E1治疗组(20例,常规治疗基础上加用前列腺素E1 0.2 μg/kg,静脉滴注1次/d);③脱氧核苷酸钠治疗组(20例,常规治疗基础上加用脱氧核苷酸钠1 mg/kg,静脉滴注1次/d);④前列腺素E1联合脱氧核苷酸钠治疗组(20例,用法用量同前),总疗程4周。结果联合组和对照组治愈率分别为85%、60%,差异有统计学意义(P<0.05)。联合组少尿期持续时间、Scr恢复时间均较单用前列腺素E1或脱氧核苷酸钠治疗组短(P <0.05);联合组尿β2-MG水平显著低于单用前列腺素E1或脱氧核苷酸钠治疗组(P <0.05),联合组尿渗透压水平显著高于单用前列腺素E1或脱氧核苷酸钠治疗组(P <0.01)。结论前列腺素E1联合脱氧核苷酸钠对儿童AKI疗效肯定,优于单用前列腺素E1或单用脱氧核苷酸钠,提示联用前列腺素E1及脱氧核苷酸钠对儿童AKI有协同治疗效应。

Objective To explore the efficacy of prostaglandin E1 combined with deoxyribo-nucleotide natrium in the treatment of children with acute kidney injury （AKI）. Methods The patients were divided into the following four groups： control group （20 cases, conventional therapy）; prostaglandin E1 group （20 cases, conventional therapy combined with 0.2μg·kg-1·d-1 prostaglandin E1 intravenously）; Deoxyribonucleotide natrium group（20 cases, conventional therapy combined with 1mg·kg-1·d-1 deoxyribonucleotide natrium intravenously）; Prostaglandin E1＋deoxyribonucleotide natrium group （20 cases, conventional therapy combined with 0.2μg·kg-1·d-1 prostaglandin E1 and 1μg·kg-1·d-1 deoxyribonucleotide natrium intravenously）. Results The recovery rate of combined treatment group and control group were 85%, 60%, respectively（P0.05）. A synergestic effects of prostaglandin E1 and deoxyribonucleotide natrium were observed in the duration of oliguria stage （P0.05）, recovery time of Scr （P0.05）, the level of urinary β2-MG （P0.05） and urine osmotic pressure （P0.01） when compared with prostaglandin E1 and deoxyribonucleotide natrium group. Conclusion There were a synergestic effects of prostaglandin E1 and deoxyribonucleotide natrium in the treatment of children with acute kidney injury.