摘要
目的探讨前列腺素E1联合脱氧核苷酸钠治疗儿童急性肾损伤(AKI)的疗效。方法实验分组:①对照组(20例,常规治疗);②前列腺素E1治疗组(20例,常规治疗基础上加用前列腺素E1 0.2 μg/kg,静脉滴注1次/d);③脱氧核苷酸钠治疗组(20例,常规治疗基础上加用脱氧核苷酸钠1 mg/kg,静脉滴注1次/d);④前列腺素E1联合脱氧核苷酸钠治疗组(20例,用法用量同前),总疗程4周。结果联合组和对照组治愈率分别为85%、60%,差异有统计学意义(P<0.05)。联合组少尿期持续时间、Scr恢复时间均较单用前列腺素E1或脱氧核苷酸钠治疗组短(P <0.05);联合组尿β2-MG水平显著低于单用前列腺素E1或脱氧核苷酸钠治疗组(P <0.05),联合组尿渗透压水平显著高于单用前列腺素E1或脱氧核苷酸钠治疗组(P <0.01)。结论前列腺素E1联合脱氧核苷酸钠对儿童AKI疗效肯定,优于单用前列腺素E1或单用脱氧核苷酸钠,提示联用前列腺素E1及脱氧核苷酸钠对儿童AKI有协同治疗效应。
Objective To explore the efficacy of prostaglandin E1 combined with deoxyribo-nucleotide natrium in the treatment of children with acute kidney injury (AKI). Methods The patients were divided into the following four groups: control group (20 cases, conventional therapy); prostaglandin E1 group (20 cases, conventional therapy combined with 0.2μg·kg-1·d-1 prostaglandin E1 intravenously); Deoxyribonucleotide natrium group(20 cases, conventional therapy combined with 1mg·kg-1·d-1 deoxyribonucleotide natrium intravenously); Prostaglandin E1+deoxyribonucleotide natrium group (20 cases, conventional therapy combined with 0.2μg·kg-1·d-1 prostaglandin E1 and 1μg·kg-1·d-1 deoxyribonucleotide natrium intravenously). Results The recovery rate of combined treatment group and control group were 85%, 60%, respectively(P0.05). A synergestic effects of prostaglandin E1 and deoxyribonucleotide natrium were observed in the duration of oliguria stage (P0.05), recovery time of Scr (P0.05), the level of urinary β2-MG (P0.05) and urine osmotic pressure (P0.01) when compared with prostaglandin E1 and deoxyribonucleotide natrium group. Conclusion There were a synergestic effects of prostaglandin E1 and deoxyribonucleotide natrium in the treatment of children with acute kidney injury.
出处
《海南医学》
CAS
2011年第9期11-13,共3页
Hainan Medical Journal
关键词
急性肾损伤
儿童
前列腺素E1
脱氧核苷酸钠
Acute kidney injury
Child
Prostaglandin E1
Deoxy ribonucleotide natrium