依达拉奉对百草枯中毒患者超敏C-反应蛋白的影响及意义

Effection and significance of edaravone on hs-CRP in patients with paraquat intoxication

目的研究依达拉奉对急性百草枯中毒患者超敏C-反应蛋白(hs-CRP)的影响及其临床意义,并探讨hs-CRP与中毒程度及预后的关系。方法将急性百草枯中毒患者随机分为常规治疗组(简称对照组)及依达拉奉治疗组(简称治疗组),另外将对照组、治疗组患者再分为多器官功能障碍综合征(MODS)组和非MODS组,于入院当天及治疗后第3、7、14、21天分别抽取外周静脉血检测hs-CRP水平。结果两组患者治疗前hs-CRP水平差异无统计学意义(P>0.05);治疗3、7、14、21 d后,两组患者hs-CRP均明显升高,差异有显著统计学意义(P<0.01);但依达拉奉治疗组升高不明显(P<0.01),两组患者中的MODS组与非MODS组hs-CRP水平比较差异有统计学意义(P<0.01)。结论 hs-CRP可作为百草枯中毒患者病情程度的观察指标,血清hs-CRP水平与中毒后MODS的发生关系密切,依达拉奉可降低急性百草枯中毒患者hs-CRP水平,对急性百草枯中毒具有明显的治疗作用。

Objective To study the effect and significance of edaravone on hs-CRP patients with acute paraquat intoxication,and discuss the relationship between the hs-CRP and poisoning degree and prognosis.Methods Acute paraquat intoxication patients were randomly divided into the routine treatment group（hereinafter referred to as the control group）and treatment group with edaravone（hereinafter referred to as the treatment group）.The control group and treatment group were further divided into MODS group and the without MODS group,in the first day and hospital after treatment 3,7,14,21 days respectively extraction peripheral blood test hs-CRP levels.Results The difference of hs-CRP levels of two groups before treatment was statistically significant（P0.05）.Treated 3,7,14,21 days,hs-CRP level of two groups were significantly increased,there was a significant statistically difference（P0.01）,But edaravone in treatment group rised not obvious（P0.01）,two groups of patients in groups with MODS and without MODS group hs-CRP levels comparative differences were statistically significant（P0.01）.Conclusions The hs-CRP as paraquat intoxication patients had a degree of observing indexes,serum hs-CRP levels and poisoning after the occurrence of MODS closely,edaravone can reduce CRP levels of hs-acute paraquat intoxication.It has obvious clinical effect.