肝硬化病人血清甲状腺激素水平的改变

Alteration of serum thyroid hormones in hepatic cirrhosis

目的观察肝硬化病人血清甲状腺激素的改变。方法用放射免疫分析法检测30例肝硬化病人和10例健康人的血清甲状腺激素水平，用Child-Pugh积分评价病人的肝功能。结果肝硬化病人血清TT3、TT4、FT3、FT4均明显低于健康人，降低的程度与肝功能损害明显相关，rT3高于健康人，而两者之间TSH水平无明显差异。结论肝硬化常伴有低甲状腺激素水平，且随着肝功能损害的加重而逐渐降低。

Objective In order to investigate the alteration of serum thyroid hormones. Methods Serum thyroid homione levels in 30 patients with hepatic cirrhosis and 10 healthy controls were measured by RIA. Hepatic functions of patients were estimated with Child-Pugh scores. Results The serum TT3,FT3, TT4, FT4 levels in patients with cirrhosis were lower than healthy controls. The rT3 levels were higher than healthy controls. The falls of TT3, FT3, TT4, FT4 were ltedrea to hepatic function.The TSH levels between them were no significant difference. Conclusion The patients with hepatic cirrhosis often have lower serum thyroid hormone levels. With the development of hepatic failure,thyroid hormones were gradually decreased.