老年急性冠脉综合征患者动脉僵硬度、内皮功能相关性研究

Study of large arterial stiffness and endothelial function in senile patients with acute coronary syndrome

目的:探讨动脉僵硬度、内皮功能与老年急性冠脉综合征患者发生冠脉事件的相关性研究。方法:采用动脉脉搏波传导速度测定仪评价动脉僵硬度和高频超声检测仪测量评价内皮功能。结果:老年急性冠脉综合征组动脉僵硬度和内皮功能异常明显低于其他两组(P<0.05),动脉僵硬度和内皮功能异常与冠脉事件呈正相关(分别为0.406、0.443;P<0.05)。结论:动脉僵硬度和内皮功能异常可能是老年急性冠脉事件的有效预测指标之一,动脉僵硬度增加和内皮功能异常可能加剧动脉粥样硬化斑块的不稳定,与斑块破裂有关。

Objective：To explore the relationship between arterial stiffness,endothelial function and coronary event in senile patients with acute coronary syndrome.Methods：According to clinic data,there were divided into 3 groups：senile patients with ACS group（n=62）,senile patients with no ACS group（n=46） and senile health control group（n=60）.Automatic pulse wave velocity measuring system was applied to examine carotid-femoral PWV as an index reflecting arterial stiffness.Ultrasound was applied to examine the flow-mediated vasodilataion of the brachial artery as an index reflecting endothelial function.Results： arterial stiffness in group of senile patients with acute coronary syndrome was significantly higher than that of other groups（P0.05）.Endothelial function in group of senile patients with acute coronary syndrome was significantly lower than that of other groups（P0.05）.A significant positive correlation between arterial stiffness,endothelial function and coronary event was found in all of the subjects（P0.05）.Conclusions： arterial stiffness and endothelial function are indicative indexes for acute coronary syndrome.they seriously promote artherosclerosis,and might perhaps cause atherosclerosis plaque destory.