阿托伐他汀对老年高血压患者踝臂指数和脉搏波传导速度的影响

Effects of atorvastatin on pulse wave velocity and ankle-brachial index in elderly people with essential hypertension

目的探讨阿托伐他汀对老年高血压患者踝臂指数(AB I)和脉搏波传导速度(PWV)的影响。方法选择96例老年高血压患者,随机分为对照组50例和阿托伐他汀组46例,常规治疗时,对照组加服安慰剂1片/d,阿托伐他汀组口服20 mg阿托伐他汀,每晚1次。治疗3个月,比较治疗前后血压、血脂、PWV、AB I的变化。结果阿托伐他汀组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)较治疗前明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)明显升高。两组患者治疗后收缩压(SBP)、舒张压(DBP)和脉压差(PP)较治疗前均有不同程度的降低(P<0.05)。与对照组治疗后相比,阿托伐他汀组SBP、PP减少明显(P<0.05)。两组患者治疗后PWV较治疗前减少,AB I较治疗前增加(P<0.05);与对照组治疗后相比,阿托伐他汀PWV降低的程度、AB I增加的程度均更加明显(P<0.05)。结论阿托伐他汀可降低老年高血压患者血压,减少PWV,增加AB I。

Objective To investigate the effect of atorvastatin on pulse wave velocity（PWV）and ankle-brachialindex（ABI）in elderly people with essential hypertension.Methods 96 elderly patients with essential hypertension were randomly divided into two groups as the control group（n=50）and the treatment group（n=46）,Each group received regular anti-hypertension treatment,the treatment group were adminisrered orally atorvastatin（20mg/d）for three months.Blood pressure,blood fat,PWV and ABI were examined in all the patients before or after the treatment.Results Serum total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）and triglyceride（TG）in the patients with atorvastatin treatment decrease more,but high-density lipoprotein cholesterol（HDL-C）increase more（P0.05）.The levels of SBP,DBP and PP were low in the both two groups,and the decrease degree of SBP or PP was more,compared with the control group（P0.05）.In addition,PWV were more decreased and ABI increased more after than before the treatment in two groups（P0.05）.However,compared with control group,the degree of decrease on PWV and increase on ABI in atorvastatin group were more（P0.05）.Conclusion Atorvastatin can reduce blood pressure,decrease PWV and increase ABI in elderly people with essential hypertension.