产妇及其新生儿人巨细胞病毒感染状况研究

A SEROEPIDEMIOLOGIC SURVEY ON HCMV REACTIVATION INFECTION STATUS IN PREGNANT WOMEN AND THEIR INFANTS.

本文采用酶联免疫吸附测定法（ELISA）分析了沈阳地区产妇及其新生儿血清中人巨细胞病毒（HCMV）的感染情况。结果发现，231例产妇血清中HCMVIgG阳性率为100％，IgM阳性率达15．58％（36／231），产妇妊娠期间HCMV感染均为激活感染。231例新生儿先天性感染率为1．73％（4／231）。产妇与其新生儿HCMV-IgM检出情况密切相关的（ra＝0．706），胎儿可以从其HCMV-IgM阳性的母亲获得先天性感染（8．33％）。此外，HCMV-IgM阳性的产妇其新生儿Apgar评分低于正常产妇的新生儿，二者之间有显著性差异（t＝3．02，P＜0．05）。

This paper was to determine the status of HCMV infection in pregnant women and their infants. A total of 231paired sera specimens, which collected from the pregnant women and their infants in Shenyang, were tested for HCMV specificantibody with indirect ELISA. The positive rates of HCMV IgG and IgM of pregnant women were 100%, 15. 58% (36/231 ) respectively. The POSitive rates of HCMV IgM in cord serum of their infants was 1. 73 % (4/231 ). The result suggested that theHCMV postinfection in pregnant women might be common. The close relation of HCMV-IgM levels between mothers and theirinfants indicated that infants might acquire congenital infection from their mothers with positive HCMV-IgM [8.33% (3/36)].