泰兴地区肝癌高发因素研究

STUDY ON HEPATOCARCINOGENIC FACTORS IN HIGHER INCIDENCE REGIONS OF TAIXING COUNTY.

探讨了泰兴地区人群肝癌的高发因素。采用ELISA法分别检测人群体内HBV感染水平和AFT—SHA含量及生活饮用水水体内MC含量。结果发现该地区人群HBsAg携带率为29．5％，HBV感染阳性率68.1％，肝癌高发乡镇人群HBsAg携带率和HBV感染阳性率分别高达45．8％和94．7％；人群体内AFT—HSA检出率达100％，平均含量为16．39pg／ng；高发乡镇人群体内AFT—HSA平均含量31．99pgM；生活饮用水水体内MC阳性检出率13．2％，河水、沟塘水和浅井水内MC的平均含量分别为36ng／L，29ng／L和25ng／L．结论：人群中的HBV高感染；黄曲霉素强暴露；生活饮用水水体内MC的普遍污染是泰兴地区肝癌高发的三个重要因素．

The factors of higher incidence of hepatic cancer were investigated in Taixing region. The infection level of HBVin residents, contain of AFT-SHA in residents and MC contain in drinking water were detected by elisa. Results found that inlocal residents the carrying rate of HBsAg was 29. 5%, the infection rate of HBV was 68. 1%. The carrying rate of HBsAg andinfection rate of HBV in higher incidence regions were up to 45. 8% and 94. 7%, respectively. The detection rate of AFT-HASin residents was 100% with the average value of 16. 39pg/ng, while the average value in higher incidence regions was 31. 99pg/ng. The detection rate of MC in drinking water was 13. 2% with average value 36ng/L, 29ng/L and 25ng/L in the water ofrivers, ditches and well, respectively. It is indicated that the three factors including higher infection rate of HBV in residents, higher exposure to aflatoxin and contamination of MC in drinking water are main hepatocarcinogenic parameters in higher incidenceregions of Taixing County.