口服脊髓灰质炎疫苗免疫儿童对四川Ⅰ型脊髓灰质炎病毒的抗体水平

ANTIBODY LEVEL AGAINST SICHUAN TYPE Ⅰ POLIOVIRUS IN CHILDREN IMMUNIZED WITH O RAL POLIOMYELITIS VACCINE.

目的：为了解我国口服脊髓灰质炎（以下简称脊灰）疫苗（OPV）按现行免疫程序接种后，被免疫儿童对四川1型脊灰病毒的免疫水平，以指导预防、控制乃至消灭脊灰策略的制定。方法：应用微量中和试验方法检测血清中对三种毒株的中和抗体滴度。结果：儿童基础兔疫后对三种毒株Sabinl、Mahoney、四川株的阳性率为100％，免后GMT分别为1196．8、317．9、62．9。结论：免疫儿童对四川Ⅰ型脊灰病毒抗体的GMT较SabinⅠ型和Mahoney低．但OPV能诱生抗四川株的抗体，OPV对四川Ⅰ型脊灰病毒是有效的。

Objective: To acknowledge immunization status on Sichuan type Ⅰ poliovirus after routine immunization.Method: 80 sera were detected by microtitration neutralization in children pre- and post-OPV administration to find out the antibody level against Sabin Ⅰ, Mahoney and Sichuan poliovirus strains. Results: The seropositive rates were all 100%, GMT was1196. 8, 317. 9 and 62. 9 respectively for the above 3 strains after OPV administration. Conclusions: post-OPV administration antibody level against Sichuan strain was lower than that of Sabin Ⅰ and Mahoney strains. But OPV could induce antibody againstSichuan type Ⅰ poliovirus. therefore OPV was effective with Sichuan type Ⅰ poliovirus.