Mg^(2+)对急性脑梗死患者血浆内皮素-1含量的影响

Influence of magnesium ion on plasma endothelin1 levels in acute cerebral infarction

目的：研究 Ｍｇ２＋ 对急性脑梗死（ Ａ Ｃ Ｉ）患者血浆内皮素 １（ Ｅ Ｔ １）含量的影响，进而探讨 Ｍｇ２＋ 对缺血神经元的保护作用机制。方法：采用放射免疫分析法测定注射 Ｍｇ２＋ 前后 Ａ Ｃ Ｉ患者血浆 Ｅ Ｔ １ 含量。结果： Ｍｇ２＋ 可降低急性脑梗死患者血浆 Ｅ Ｔ １ 含量， Ａ Ｃ Ｉ患者血浆 Ｅ Ｔ １ 由（２２７３±１３１７）ｎｇ／ Ｌ 降至（１５２２±１１６５） ｎｇ／ Ｌ， Ｐ＜ ００１。结论： Ｍｇ２＋ 通过降低急性脑梗死患者增高的 Ｅ Ｔ １，对缺血神经元起到保护作用。

Objective:To study the effect of magnesium ion on plasma endothelin1(ET1) levels in acute cerebral infarction (ACI) and the mechanism underlying the protective effect of magnesium ion on ischemic neuron.Methods:Plasma ET1 levels were determined by radioimmunoassay in ACI patients before and after injection of magnesium ion.Results:Following magnesium ion treatment,plasma ET1 levels were signi ficantly decreased compared to that before treatment in ACI patients 〔(22 73±13 17)ng/L vs.(15 22± 11 65)ng/L , P <0 01〕.Conclusions:The results suggest that magnesium ion can protect the ischemic neurons through decreasing the elevation of ET1 levels in patients with ACI.