摘要
基于经典HP模型,利用蛋白质序列的矩阵图谱表达法(MGR)及数值刻画的思想提出了一种新的蛋白质序列的比对方法,通过观察蛋白质序列的数值刻画图及计算两蛋白质序列之间的欧氏距离d,对木聚糖酶两家族的蛋白质序列进行了相似性分析.发现被划分为同一木聚糖酶家族的蛋白质序列之间的相似性更大,而且蛋白质序列的相似性程度与分子大小、结构和分子进化相关.
By using the matrix graphical representation of protein（MGR） and numerical characterization based on the detailed HP model,a new method of aligning two protein sequences was given.By observing the numerical characterization graphs of protein sequences and computing the Euclidean distance d between that two sequences,the similarity of protein sequences in two xylanase families was analyzed.The results indicated that： the protein sequences which belong to the same family of xylanase have greater similarity,and the degree of similarity is related to the molecular size,structure and molecular evolution.
出处
《生命科学研究》
CAS
CSCD
2011年第2期101-106,124,共7页
Life Science Research
基金
江南大学创新团队发展计划(PIRTJiangnan)资助
财政部专项"外来物种环境风险评估技术研究"资助(200709017)
关键词
经典HP模型
矩阵图谱表达
相似性
木聚糖酶
the detailed HP model
matrix graphical representation of protein（MGR）
similarity
xylanase
