微波辐射合成秦皮乙素的研究

Study on the synthesis of esculetin under microwave irradiation

以无水氯化锌为催化剂,采用微波辐射,由1,2,4-苯三酚与丙炔酸乙酯发生环化反应制备秦皮乙素。结果表明,微波辐射合成秦皮乙素的最佳反应条件为∶n(1,2,4-苯三酚)∶n(丙炔酸乙酯)=1.0∶1.0,3.5 g氯化锌,反应时间10 min,反应温度105℃,微波功率400 W,产率可达87.4%。

Esculetin was obtained by the cyclization of 1,2,4-benzenetriol and ethyl propionate using ZnCl2 as catalyst under microwave irradiation.The optimum reaction conditions were as follows：n（1,2,4-benzenetriol） ∶n（ethyl propionate）=1.0∶1.0,3.5 g ZnCl2,10 min,105 ℃ and microwave power 400 W.The yield reached 87.4 %.