盐酸硫胺催化合成苯甲醛乙二醇缩醛

Catalytic synthesis of benzaldehyde glycol acetal over VB_1

采用绿色环保的盐酸硫胺(VB1)催化苯甲醛和乙二醇缩醛反应,系统考察了醇醛物质量比、催化剂用量以及反应时间对产品收率的影响。最佳的工艺条件为苯甲醛和乙二醇物质的量比为1∶1.8(摩尔比)、催化剂用量为反应物料总质量的0.2%、带水剂环己烷10 mL、反应时间为1.0 h。在此反应条件下,苯甲醛乙二醇缩醛的收率可达87.2%。

The benzaldehyde glycol acetal was synthesized from benzaldehyde and glycol using VB1 as the green catalyst.The effect of molar ratio of alcohol to aldehyde,catalyst amount and reaction time on yield was studied.The best conditions were as follows： the molar ratio of benzaldehyde to glycol was 1 ∶1.8,the mass ratio of the catalyst to the reactants was 0.2%,water-carrying agent of cyclohexane was 10 mL and the reaction time was 1.0 h.Under these conditions,the yield of benzaldehyde glycol acetal was up to 87.2%.