尿钙法评价碳酸钙片的人体相对生物利用度

Evaluating Relative Bioavailability of Calcium Carbonate Tablet with Urinary Calcium in Healthy Volunteers

目的：研究碳酸钙片的相对生物利用度。方法：8名健康男性志愿受试者在口服碳酸钙片和磷酸氢钙片后的尿钙，以参数mg／mgCr和mg／LGF来评价钙的经肠吸收，并对试验数据进行统计分析。结果：口服2种制剂后0h～2h和2h～4h的尿钙增量无显著性差异（P＞0．05）;服药后4h尿钙的总排泄量及增量亦无显著性差异（P＞0．05）；以2种制剂服药后4h的尿钙总排泄量相比，碳酸钙片的相对生物利用度为（102．92±13．21）％。结论：碳酸钙片与磷酸氢钙片经口服后是生物等效制剂。

OBJECTIVE: To study the relative bioavailability of calcium carbonate tablet in healthy volunteers. METHODS: Theurinary calcium following calcium carbonate tablet or calcium phosphate tablet being orally giving to & volunteers was calculatedaccording to urinary calcium in mg/ mg creatinine or urinary calcium in mg/ L glomerular filtrate. Comparisons were made between two groups using the paired t--test. RESULTS: There was no difference between the two formulations in the incrementof urinary calcium from 0 to 2 hour and from 2 to 4 hour post--load, or the urinary calcium from 0 to 4 hour post -- load(P >0. 05). The relative bioavailability of calcium carbonate tablet was (102. 92 1 13. 21) %. CONCLUSION: The two formulationswere bioequivalent.