卡托普利对高血压病患者血糖、胰岛素、脂蛋白水平影响的研究

Effects of captopril on Glucose, Insulin, and Lipoprotein \;in hypertensive

目的：探讨卡托普利对高血压病患者血糖、胰岛素、脂蛋白水平的影响。 方法：将 ６４ 例高血压病患者给予卡托普利治疗 ３ 月后，观察其血糖、胰岛素、脂蛋白水平的变化。 结果：３ 月后， 患者收缩压、舒张压均显著降低（ Ｐ＜ ０．０１），用餐后血糖和胰岛素分别由 ９．９８±４．６ ｍ ｍ ｏｌ／ Ｌ和 １３８±１８ ｍ Ｕ／ Ｌ降至 ７．１±１．８ ｍ ｍ ｏｌ／ Ｌ 和 １０１ ±３０ ｍ Ｕ／ Ｌ（ Ｐ均＜０．０１）； Ｔ Ｃ、 Ｔ Ｇ、 Ｌ Ｄ Ｌ┐ Ｃ、ａｐｏ Ｂ显著降低，而 Ｈ Ｄ Ｌ┐ Ｃ、ａｐｏ Ａ Ｉ显著升高（ Ｐ＜ ０．０５， Ｐ＜ ０．０１）。 结论：卡托普利在降压的同时能改善胰岛素抵抗，并可降低高血压患者冠状动脉硬化性心脏病的危险性。

Objective:To explore the effects of captopril on the concentrations of glucose, insulin and lipoprotein in plasma in the patients with hypertension. Method:The concentrations of glucose, insulin and lipoprotein were weasured both before and after receiving captopril for 3 months. Results:The SBP and DBP decreased highly ( P <0.01) , and the concentrations of glucose and insulin in plasma decreased from 9.98±4.6 mnol/L and 138±18 mU/L to 7.1 ± 1. 8 mmol/L and 101±30 mU/L respectively( P <0.01). The TC、TG、LDL C, apoB in decreased and the HDL C,apo A1 creased significantly ( P <0.05, P <0.01). Conclusion:Captopril can improve insulin resistance and decrease the risk of coronary atherosclerosis heart disease in patients with hypertension.