肥厚心肌组织血管紧张素Ⅱ、醛固酮水平与心肌糜酶样活力改变的关系

Relation Between Alteration in Myocardium Chymase like Activity and AngiotensinⅡ,Aldosteron Contents in Pressure Overload Hypertrophy Rat

目的：探讨在压力负荷性心肌肥厚过程中，肥厚心肌组织血管紧张素、醛固酮水平与糜酶样活性改变及其相关性。 方法：采用缩窄大鼠腹主动脉造成压力负荷性心肌肥厚模型，测定术后 ２、６、１２ 周心肌组织血管紧张素、醛固酮含量及糜酶样活性，并设同期正常对照组。结果：术后２、６、１２ 周心肌肥厚组大鼠心肌组织糜酶样活性较同期正常对照组显著增高（ Ｐ＜ ０．０１）；术后 １２ 周心肌肥厚组大鼠心肌血管紧张素、醛固酮含量较同期正常对照组明显增加（ Ｐ＜ ０．０１）； 心肌组织血管紧张素、醛固酮水平与糜酶样活性呈正相关（ Ｐ＜ ０．０５）。 结论：在压力负荷性心肌肥厚过程中，有心肌组织糜酶样活性因素的参与，并影响局部血管紧张素、醛固酮代谢。

Aim:To study the relationship between chymase like activity and angiotensinⅡ,aldosterone contents in hypertrophied rat myocardium. Methods:We used model of pressure overload hypertrophy in rat. The chymase like activity and angiotensin Ⅱ, aldosterone contents in myocardium were determined 2,6,12 weeks after constriction of abdominal aorta in rats. Results: It was found that the myocardial chymase like activity increased markedly in hypertrophied rat (2,6,12 weeks); the angiotensinⅡand aldosterone contents increased significantly in hypertrophied rat (12 weeks); and the myocardium angiotensin Ⅱ, aldosterone levels correlated positively to the myocardium chymase like activity . Conclusion: Myocardium chymase like activity may be involved in myocardial hypertrophy and effect the metabolism of angiotensinⅡ and aldosterone.