甘露醇对颅脑手术患者胶体渗透压与电解质的影响

Effects of Mannitol on Plasma Colloid Osmotic Pressure and Electrolyte in Patients Undergoing Craniotomy

目的观察颅脑手术期间静脉输注甘露醇对血浆胶体渗透压和电解质的影响。方法选择美国麻醉医师协会（ASA）分级Ⅰ-Ⅱ级择期行颅脑手术患者48例,分别检测静脉输注20%甘露醇250 mL前、输注后即刻和输注后30 min血浆胶体渗透压及电解质。结果甘露醇输注后即刻血浆胶体渗透压较输注前降低13.9%,输注30 min后回升;甘露醇输注后30 min钾离子（K＋）浓度升高,钠离子（Na＋）浓度降低。结论颅脑手术期间输注甘露醇,可引起一过性血浆胶体渗透压降低,K＋升高,Na＋降低。

Objective To investigate the infusion of mannitol on plasma colloid osmotic pressure（COP） and electrolyte in patients undergoing craniotomy. Methods 250 mL 20% mannitol was infused in forty eight ASA Ⅰ～Ⅱ patients undergoing elective craniotomy.The plasma COP and electrolyte were measured before infusion,just right after infusion,and 30 min after infusion. Results By the end of the infusion,COP decreased significantly and increased again 30 min after infusion.K＋ was increased and Na＋ was decreased 30 min after infusion. Conclusion Infusion of mannitol during craniotomy may lead to a transient drop of COP,Na＋ decline,and K＋ elevation.