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阿司匹林联合银杏叶制剂降低阿司匹林抵抗50例 被引量:9

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摘要 目的观察银杏叶制剂对阿司匹林抵抗的影响。方法将100例急性冠状动脉综合征患者分为治疗组和对照组各50例,均服用阿司匹林100 mg.d-1,连续服用14 d;治疗组加用银杏叶制剂,连续14 d。治疗2周后采静脉血,测定经花生四烯酸(AA)、二磷酸腺苷(ADP)和血小板活化因子(PAF)诱导的血小板聚集率。结果与对照组比较,治疗组3种不同途径的血小板聚集率均下降,PAF途径的血小板聚集率显著下降,阿司匹林抵抗和阿司匹林半抵抗总发生率较对照组明显下降。结论银杏叶制剂与低剂量阿司匹林联用能明显降低阿司匹林抵抗,减少不良心血管事件的发生。
出处 《医药导报》 CAS 2011年第5期614-615,共2页 Herald of Medicine
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参考文献7

  • 1WEBER A A,PRZYTULSKI B,SCHANZ A,et al.Towards a definition of asprin resistance:a typological approach[J].Platelets,2002,13(1):37-40.
  • 2HART R G,LEONARD A D,TALBERT R L,et al.Asprin dosage and thromboxane synthesis in patients with vascular disease[J].Pharmacotherapy,2003,23:579-584.
  • 3QUINN M J,ARNOW H D,CALIFF R M,et al.Asprin dose and six-month outcome after an acute coronary syndrome[J].Jam Coll Cardiol,2004,43(6):927-928.
  • 4EIKELBOOM J W,HANKEY G J.Asprin resistance:a new independent predictor of vascular events[J].Jam Coll Cardiol,2003,41(6):966-968.
  • 5吴建华,朱健华.阿司匹林抵抗的研究进展[J].南通大学学报(医学版),2007,27(4):327-328. 被引量:3
  • 6WEBER A A,ZIMMERMANN K C,MEYER-KIRCHRATH J,et al.Cyclooxygenase-2 in human platelets as a possible factor in asprin resistance[J].Lancet,1999,353(9156):900-904.
  • 7CIPOLLONE F,TONIATO E,MARTINOTTI S,et al.Identi-fication of New Elemnets of Plaque Stability(INES) Study Group.A polymorphism in the cyclooxygenase-2 gene as an inhetited protective factor against myocardial infarction and storke[J].JAMA,2004,291(18):2221-2228.

二级参考文献27

  • 1李小鹰.阿司匹林在动脉硬化性心血管疾病中的临床应用:中国专家共识(2005)[J].中华心血管病杂志,2006,34(3):281-284. 被引量:193
  • 2[1]Antithrombotic Trialists' Collaboration.Collaborative metaanalysis of randomized trials of antiplatelet therapy for prevention of death,myocardial infarction,and stroke in high risk patients[J].BM J,2002,324,732a:71-86.
  • 3[2]Gum PA,Kottke K,Poggio ED.Profile and prevalence of aspirin resistance in patients with cardiovascular disease[J].Am J Cardiol,2001,88(3):230-235.
  • 4[3]Hennekens CH,Schior K,Weisman S,et al.Terms and conditions:Semantic complexity and aspirin resistance[J].Circulation,2004,110 (12):1706-708.
  • 5[4]Sanderson S,Emery J,Baglin T,et al.Narrative review:Aspirin resistance and its clinical implications[J].Ann Intern Med,2005,142 (5):370-380
  • 6[5]Weber AA,Przytulski B,Schanz A,et al.Towards a definition of aspirin resistance:a typological approach[J].Platelets,2002,13 (1):37-40.
  • 7[6]Wang TH,Bhatt DL,Topol EJ.Aspirin and clopidogrel resistance:An emerging clinical entity[J].Eur Heart J,2006,276(6):647-654.
  • 8[7]Michelson AD.Platelet function testing in cardiovascular diseases[J].Hematology,2005,10(1):132-137.
  • 9[8]Hart RG,Leonard AD,Talbert RL,et al.Aspirin dosage and thromboxane synthesis in patients with vascular disease[J].Pharmacotherapy,2003,23:579-584.
  • 10[9]Quinn MJ,Arnow HD,Califf RM,et al.Aspirin dose and six-month outcome after an acute coronary syndrome[J].J Am Coll Cardiol,2004,43:972-928.

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