微波辐射下AlCl_3·6H_2O催化合成β-烯胺酮

AlCl_3·6H_2O catalyzed synthesis of β-enaminones under microwave radiation

目的对β-烯胺酮类化合物的微波合成方法的研究。方法在微波辐射下,功率为160W,用AlCl3.6H2O作为催化剂,无溶剂条件下,使乙酰丙酮和1,3-环己二酮分别与一系列胺类化合物反应1～20 min,合成出目标产物。结果合成出的一系列β-烯胺酮类化合物,用红外,1HNMR和元素分析表征了目标化合物的结构;产率为80%～99%。结论该方法具有无溶剂,反应条件温和,操作简单,产率高,反应时间短和产物易分离等优点,是合成β-烯胺酮类化合物的理想方法。

Aim To research the method for microwave-assisted synthesis of β-enaminones.Methods Using AlCl3·6H2O as catalyst,the reaction of acetylacetone or 1,3-dioxocyclohexane and amines was processed under microwave radiation from 1 min to 20 min to give the corresponding β-enaminones under solvent-free condition.Results The structure of the compounds was confirmed by IR,1H NMR and elementary analysis.The yield of the target is 80%～99%.Conclusion The methods were mild,simple and available for synthesis of β-enaminones in good yields without use of solvent.