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先天性心脏病相关转录因子NK-2的研究进展

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摘要 心脏是脊椎动物胚胎发育过程中最早形成的功能器官，它由不同胚层来源的细胞发育而来，是各种细胞经过精准的特化、迁移和组织结构折叠、屈曲的结果。这一系列复杂的形态变化及精细的血流动力学改变均由一个核心转录因子调控网络控制，其中包括NK-2、HAND、GATA以及TBX等。该调控网络将上游诱导信号与下游调控基因联系起来，控制心肌分化和增殖、心脏发育模式及形态发生和心脏收缩。在控制心脏发育的核心转录因子调控网络中，
作者 张永波 仇小强
机构地区 桂林医学院附属医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2011年第8期1069-1071,共3页 Guangdong Medical Journal
基金 广西自然科学基金重点项目(编号:2010GXNSFD013054)
关键词 相关转录因子 先天性心脏病 胚胎发育过程 调控网络 动力学改变 脊椎动物 细胞发育 组织结构
分类号 R68 [医药卫生—骨科学]
  • 相关文献

参考文献26

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二级参考文献36

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共引文献15

广东医学
2011年 第8期

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