FAS-1377基因多态与胃癌风险

FAS-1377 POLYMORPHISMS AND RISK OF GASTRIC CANCER

目的研究FAS-1377基因多态性与胃癌风险的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,检测青海胃癌患者和正常人的FAS-1377基因多态性,用χ2检验分析其基因多态性与胃癌风险间的关系。结果胃癌组中FAS-1377基因多态分布为纯合野生型GG频率7.4%(7/95)、杂合型GA频率61.1%(58/95)、纯合突变型AA频率31.5%(30/95)。正常对照组中FAS-1377基因多态分布为纯合野生型GG频率41.1%(53/129)、杂合型GA频率34.1%(44/129)、纯合突变型AA频率24.8%(32/129)。FAS-1377基因多态与胃癌风险间存在关联(P<0.001)。结论 FAS-1377基因多态可能与胃癌风险有明显相关性。

Objective To investigate the correlation between FAS polymorphisms and the risk of gastric cancer.Methods The polymorphisms of FAS were detected by polymerase chain reaction-restriction fragment length polymorphisms assay（PCR-RFLP） in gastric cancer patients and in health people,χ2 was applied to assess the association between the polymorphisms of FAS and gastric cancer risk.Results In gastric cancer group,the frequency of FAS-1377 GG（homozygous wild type）,GA（heterozygous type）,AA（homozygous mutant type） was 7.4%（7/95）,61.1%（58/95） and 31.5%（30/95） respectively.In the health control group,the frequency of FAS-1377GG,GA,AA was 41.1%（53/129）,34.1%（44/129） and 24.8%（32/129） respectively.The polymorphisms of FAS-1377 gene may be associated with risk of gastric cancer（P〈0.001）.Conclusion The polymorphisms of FAS-1377 gene may be associated with the risk of gastric cancer.