地方性氟中毒病区与非病区8-12岁儿童氟斑牙及与血清化学元素的关系

Relationship between dental fluorosis and serum chemical element levels of 8-12 year-old children in endemic fluorosis areas and non-diseased areas

目的了解8-12岁儿童氟斑牙患病情况,探讨化学元素与氟斑牙的关系。方法采用现况调查的方法对104例8-12岁儿童进行氟斑牙调查,了解儿童氟斑牙患病情况,依据Dean法对儿童氟斑牙进行诊断和分度,应用IRIS IntrepidⅡXSP ICP光谱仪测定血清钙(Ca)、铜(Cu)、铁(Fe)、镁(Mg)、磷(P)、锌(Zn)的含量。结果地方性氟中毒重病区、中病区、对照区8-12岁儿童氟斑牙检出率分别为93.0%,81.5%和11.8%。血清Ca、Cu、Fe、Mg、P、Zn在该三组儿童体内的分布不同(FCa=12.150,P<001;FCu=3.326,P<0.05;FFe=11.893,P<001;FMg=13.053,P<001;FP=3.131,P<0.05;FZn=28.019,P<001)。钙含量中病区低于对照区(P<0.001);铁含量中病区高于对照区(P<0.001);镁含量重病区、中病区均低于对照区(P<0.001);磷含量重病区低于对照区(P<0.05);锌含量重病区高于对照区,中病区低于对照区(P<0.05)。氟斑牙患者镁含量低于正常儿童(t=2.14,P<0.05),其余化学元素在两组的分布未见有统计学差异。结论饮水氟浓度越高,氟斑牙检出率越高。钙和镁对氟斑牙的发生有拮抗作用。

Objective To investigate the prevalence of dental fluorosis in children aged 8-12 years,and to explore the relationship between dental fluorosis and serum chemical elements.Methods The cross-sectional study was used to investigate the prevalence of dental fluorosis.The dental fluorosis was diagnosed according to Dean method.The contents of serum calcium（Ca）,copper（Cu）,iron（Fe）,magnesium（Mg）,phosphorus（P）,zinc（Zn） were determined using IRIS Intrepid Ⅱ XSP ICP spectrometer.Results The prevalence of dental fluorosis of children aged 8-12 years in severe endemic fluorosis areas,the wards,the control areas were 93.0%,81.5% and 11.8%,respectively.Serum levels of Ca,Cu,Fe,Mg,P,and Zn in the children of severe endemic fluorosis areas,the wards,the control areas were different（FCa=12.150,P001;FCu=3.326,P〈0.05;FFe=11.893,P001;FMg=13.053,P001;FP=3.131,P〈0.05;FZn=28.019,P001）.Content of calcium in the wards was lower than that in the control areas（P〈0.001）.Iron content in the wards was higher than that in the control areas（P〈0.001）.Magnesium content was lower in the severe areas and the wards than that in the control areas（P〈0.001）.Phosphorus content in severe areas was lower than that in the control zone（P〈0.05）.Zinc content in seriously ill areas was higher than that in the control areas,while it was lower in the wards than that in the control areas（P〈0.05）.Level of magnesium in dental fluorosis patients was higher than that in normal children（t=2.14,P〈0.05）,but there was no significant difference in the rest chemical elements between them.Conclusion The higher the concentration of fluoride in drinking water is,the higher the detection rate of dental fluorosis is.Calcium and magnesium can be antagonistic with dental fluorosis.