老年男性阻塞性睡眠呼吸暂停综合征与肾小球滤过功能关系研究

Obstructive sleep apnea syndrome and function of glomerular filtration in elder males:a correlation study

目的探讨老年男性阻塞性睡眠呼吸暂停低通气(OSAHS)与肾小球滤过功能的关系。方法收集2008年1月至2010年3月在解放军总医院老年心血管二科住院和门诊查体的63例相对健康老年男性,采用多导睡眠呼吸仪进行睡眠监测,同时测定血清生化指标及人体测量学指标,并进行相关和回归分析。结果符合OSAHS诊断的共33例(52.38%),与其余30例(对照组)比较,两组BMI、血糖、总胆固醇、甘油三酯、LDL差异均无统计学意义(P均>0.05)。OSAHS组年龄、肾小球滤过率(GFR)略低于对照组。单因素分析显示GFR水平与睡眠呼吸暂停综合征(r=-0.307,P=0.019)、身高(r=-0.338,P=0.010)呈负相关。多元线性回归结果显示,OSAHS是中国老年男性GFR水平降低的独立危险因素(B=-4.834,P=0.041)。结论 OSAHS可能是老年男性肾功能进展的重要合并疾病和潜在危险因子。

Objective To observe the correlation between obstructive sleep apnea syndrome and the function of glomerular filtration in elder males. Methods Between January 2008 and March 2010,63 healthy elder males registered to and undergoing physical workup in Second Department of Geriatric Cardiology of General Hospital of PLA were evaluated for sleep disorders using polysomnography sleep breathing apparatus, as well as serum biochemical indexes and anthropometry indexes. The data were analyzed with correlation and regression analysis. Results Of a total of 63 patients, 33 （52. 38% ） fulfilled diagnostic criteria of OSAHS. There were no significant differences in the BMI, blood glucose levels, total cholesterol, triglycerides, and LDL levels （ P 〉 0. 05 ） between the control group （n = 30） and the OSAHS group. The age and GFR levels of OSAHS group was a bit lower than those of the control group. Univarlate analysis showed that GFR levels were negatively correlated with sleep apnea syndrome （ r = 0. 307, P = 0. 019 ）, and height （ r = - 0. 338, P = 0. 010 ）. Moreover, multiple linear regression showed that obstructive sleep apnea syndrome was an independent risk factor of reduced GFR levels in eider Chinese males. Conclusion OSAHS may be an important co-morbidity and potential risk factor of renal function worsening in eider males.