心肺功能不全患者血乳酸浓度变化的研究

Study the changes of blood lactate concentration in the patients with respiratory failure and heart failure

目的探讨呼吸衰竭、呼吸衰竭合并急性左心功能衰竭患者血乳酸(LAC)浓度的变化,及与血氧分压(PaO2)之间的相互关系。方法用GEMpremier血气、电解质、血乳酸仪测定正常对照组、呼吸衰竭患者、呼吸衰竭合并急性左心功能衰竭患者的血LAC浓度和血气分析。结果三组患者血LAC浓度有显著性差异(P<0.01),PaO2与血LAC呈明显的负相关(P<0.01)。结论血LAC的测定有助于了解组织细胞缺氧情况,呼吸衰竭患者同时监测血气和血LAC,可帮助判断患者是否合并急性左心功能衰竭。

Objective To study the changes of blood lactate concentration in the patients with respiratory failure and acute left heart failure,and the relationship with partial pressure of arterial oxygen.Methods The blood lactate concentrations and blood gas in 116 patients（37 cases with respiratory failure,38 cases with respiratory failure and acute left heart failure,and 40 cases as control） were determined by GEM premier blood gas blood electrolyte analyzer.Results There were significant difference of blood lactate concentrations among three groups（P〈0.01）.The patients with respiratory failure and acute left heart failure had a higher blood lactate level than other groups.The significant negative correlations were found between PaO2 and blood lactate（P〈0.01）.Conclusion Determination of blood lactate level may help us to know the anoxemia condition of tissues.The blood lactate level in the patients with respiratory failure may help to distinguish with or without acute left heart failure.