长期吸入糖皮质激素对哮喘患者诱导痰SIgA含量影响及泛福舒治疗作用的临床研究

The clinic effect of concentration of SIgA in induced sputum from the asthma patients treated with steroid or and with Broncho-Vaxom

目的观察长期吸入激素对哮喘患者诱导痰中SIgA含量影响及泛福舒的治疗作用。方法选择27例轻、中度支气管哮喘患者。随机分成A、B两组,A组15例,B组12例。C组为正常对照组15例。A、B两组中初次使用舒利迭的哮喘患者定义为D组,共18例。A组给予舒利迭(沙美特罗、丙酸氟替卡松粉吸入剂50/250 ug)治疗;B组患者给予舒利迭(沙美特罗丙酸氟替卡松粉吸入剂50/250 ug)加泛褔舒(细菌溶解产物胶囊7 mg)治疗,观察时间为3月。分别采用诱导痰的方法收集痰液,检测诱导痰中SIgA含量。结果 A组治疗后较前下降,B组上升,差异均有统计学意义(P<0.05),两组间比较差异有显著性(P<0.05),D组治疗前与C组比较诱导痰中SIgA含量低,差异有显著性(P<0.05),B组治疗后SIgA含量仍低于正常对照组。结论支气管哮喘病人诱导痰中SIgA含量较正常人低,吸入激素治疗引起其进一步下降,口服免疫调节剂治疗可提高其含量,但仍不能达到正常水平。

Objective To observe the change of concentration of SIgA in induced sputum from the asthma patients treated with steroid,and or Broncho-Vaxom.Methods 27 patients were grouped to A and B randomly.Group A includes 15 patients treated with Seretide for three months,Group B includes 12 patients treated with Seretide and Broncho-Vaxom for three months.15 healthy controls named group C with no treatment were recruited.The asthma patients before treatment were named group D.Before and after the treatment the samples of induced sputum from each group were collected.The measurement of SIgA was performed with ELISA kits.Results The concentration of SIgA in group A decreased significantly after the treatment,but it increased significantly in group B.The changes between two groups were significant（P〈0.05）.The concentration of SIgA in group C was higher than that in group D and B after treatment.Conclusions The concentration of SIgA will be decreased after being treated with Steroid,and it can be increased by the Broncho-Vaxom.The concentration of SIgA of asthma patients is lower than that in group C in spite of by the treatment of the Broncho-Vaxom with some increasing of SIgA.