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VEGF与急性脑梗死的关系 被引量：5

VEGF and acute cerebral infarction
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摘要 目的观察脑梗死急性期患者血清中血管内皮生长因子(VEGF)含量的变化,并探讨其临床意义。方法采用双抗体夹心ELISA法连续测定57例脑梗死患者血清VEGF,对照组选年龄、性别相匹配体检者,入院后1 d、28 d用NH ISS分别评价脑梗死组1和组2。结果脑梗死患者急性期VEGF含量各时间点均高于健康对照组(P<0.01),最高值发生在第七天后渐下降,入院后1 d、28 d脑梗死组1和组2 NH ISS评分分别为(11.0±3.4)、(4.2±1.8)分,(10.4±2.8)、(2.8±2.1)分。结论脑梗死急性期血清VEGF含量高,入院后28 d NH ISS评分低于脑梗死急性期,且血清VEGF含量低。 Aim To observe the change of vascular endothelial growth factor（VEGF）in the serum of patients with acute cerebral infarction,and to discuss the clinical significance.Methods Double immune body ELISA was used determine serum VEGF in 57 cases of acate cerdbral infarction,NHISS was used to evaluate cerebral infarction in group 1 and group 2 at 1 d and 28 d in the control group.Results For acute cerebral infarction patient VEGF content at various time was higher than that in the healthy control group（P0.01）,the peak appeared at the seventh day and then decreesed gradually.NHISS scores of cerebral infarction group 1 and group 2 at 1 d and 28 d were（11.0±3.4）,（4.2±1.8）,（10.4±2.8） and（2.6±2.1）,respectively.Conclusion VEGF content of acute cerebral infarction at acute stage is higher,NHISS score at 28 d was lower than VEGF content of acute cerebral infarction.
作者 陈生 胡志涛
机构地区 安徽医科大学附属六安医院神经内科
出处 《安徽医药》 CAS 2011年第5期606-607,共2页 Anhui Medical and Pharmaceutical Journal
关键词 脑梗死 VEGF NHISS Cerebral infarction VEGF NHISS
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献9

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二级参考文献29

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同被引文献57

  • 1赵丽静,刘亢丁.血管内皮细胞生长因子治疗缺血性脑卒中的新思路[J].中华临床医师杂志（电子版）,2011,5(7):2022-2025. 被引量：11
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引证文献5

二级引证文献74

安徽医药
2011年 第5期

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