两种测定口服华法令患者纤维蛋白原方法的比较

Comparison of two fibrinogen assay methods in the patients intaking orally Warfarin

目的探讨两种测定纤维蛋白原（Fib）方法的临床应用价值。方法应用ACL Advanc全自动血凝仪、同时用PT衍生法（PT-der）和Clauss法测定口服华法令患者血浆Fib含量。并应用统计学方法对两种测定方法的结果进行比较。结果 Fib在2~4 g/L时,结果差异无统计学意义（P〉0.05）,在Fib〈2 g/L或Fib〉4 g/L时,差异有统计学意义（P〈0.05）。结论应用ACL Advance全自动血凝仪测定口服华法令患者的Fib时,当PT-der法测定出的Fib结果不在2~4 g/L时,需要用Clauss法进行测定。

Objective To investigate the clinical application value by comparing with the two fibrinogen assay methods.Methods ACL-advance automatic coagulometer was used,and the contents of FIb were detected by PT-der and Clauss assay methods.Then we compared the result of the two methods statistically.Results There was no statistical difference when the concentration of fibrinogen was in the range of 2-4 g/L（P〉0.05）.But the difference was significant when the concentration of fibrinogen was out of normal range（P〈0.05）.Conclusion If the results are out of the range of 2-4 g/L with PT-der assay when using ACL-advance to test the fibrinogen of patients orally taking Warfarin,it is necessary to redo the test by Clauss assay.