阿托伐他汀钙对喀什地区高血压患者超敏C反应蛋白的疗效观察

Clinical observation on the effect of atorvastatin calcium on high sensitive C-reactive protein in Uygur patients with essential hypertension from Kashgar region

目的观察阿托伐他汀钙对新疆喀什地区维吾尔族高血压患者超敏C反应蛋白(hs-CRP)的影响。方法选取2008年12月至2009年12月hs-CRP高于正常值的维吾尔族高血压患者140例作为治疗组,每天服用阿托伐他汀钙20 mg,对照组为同期维吾尔族高血压患者。于服药后2个月抽血检查hs-CRP水平。实验室检查采用免疫比浊法。结果治疗组服用阿托伐他汀钙2个月后hs-CRP较前明显下降,治疗组与对照组比较,差异有统计学意义(P<0.01)。结论维吾尔族高血压患者服用阿托伐他汀钙可降低炎症因子hs-CRP,这对改善高血压患者的远期预后具有重要意义。

Objective To observe the effect of atorvastatin calcium on high sensitive C-reactive protein（hs-CRP） in Uygur patients with essential hypertension from Kashgar region of XinJiang.Methods From Dec.2008 to Dec.2009,we took 140 Uygur patients with essential hypertension whose serum levels of hs-CRP were higher than normal people as the treatment group,intaking atorvastatin calcium tablet 20 mg every day,and the Uygur patients with essential hypertension were treated as the control group in the same period.Immunoturbidimetry was used to measure the levels of serum hs-CRP after intaking atorvastatin calcium for two months.Results After intaking atorvastatin calcium for two monthes,the level of serum hs-CRP of the treatment group was significantly decreased.The result presented a significant difference between the treatment and control group（P〈0.01）.Conclusion After taking atorvastatin calcium,the levels of serum hs-CRP will decrease in Uygur patients with essential hypertension.It is a significant improvement for the long-term prognostic of patients with essential hypertension.