血清Dickkopf相关蛋白1水平与肺癌及其病理类型的相关性分析

Correlation analysis of the serum DKK1 level,lung cancer,and its pathological types

目的探讨血清Dickkopf相关蛋白1(DKK1)水平与肺癌及其病理类型之间的相关性。方法收集101例经纤支镜活检或病理切片确诊的肺癌患者和102例健康体检者。101例肺癌患者中鳞癌55例,腺癌16例,小细胞性肺癌30例。所有对象均测定血清DKK1、细胞角蛋白19片段抗原(Cyfra21-1)水平,并进行组间比较。结果与对照组比较,肺癌各组DKK1水平均有明显升高,差异有统计学意义(P<0.05)。肺癌各病理分组中DKK1水平为小细胞性肺癌组最高,鳞癌次之,腺癌最低。组间比较差异无统计学意义(P>0.05)。结论血清DKK1水平的升高可能与肺癌的发生相关,但与其病理类型无关。

Objective To investigate the association between serum Dickkopf 1（DKK1） level,lung cancer,and its pathological types.Methods 101 patients with lung cancer diagnosed by bronchoscopic biopsy or Pathological section,including 55 cases of squamous cell carcinoma,16 cases of adenocarcinoma and 30 cases of small cell lung cancer,and 102 healthy individuals were enrolled in this study.Serum DKK1 and Cyfra21-1 level of all subjects were measured.Difference comparison of measured data among groups was determined by single factor variance analysis.Results Comparing with the control group,the mean level of DKK1 in patients with lung cancer was significantly higher than the samples in the control group（P〈0.05）.There was no significant difference between different histological types of lung cancer（P〉0.05）.The serum level of DKK1 was the highest in squamous cell carcinoma,followed by adenocarcinoma and small cell lung cancer.Conclusion Serum level of DKK1 is related to the lung cancer but not related to its pathological types.