非淋菌性尿道炎患者支原体培养和药敏试验结果分析

Analysis of mycoplasma infection and drug resistance of the patients with non-gonococcal urethritis

目的了解泌尿生殖道解脲支原体(Uu)和人型支原体(Mh)感染情况及药物情况,以指导临床合理用药。方法采用珠海黑马生物工程公司生产的支原体试剂盒对Uu和Mh进行检测及对12种抗菌药物进行药物敏感试验,并对结果进行统计学分析。结果 957例患者标本检出支原体426例,占总人数的44.5%。Uu阳性360例,占支原体阳性的84.4%;Mh阳性8例,占支原体阳性的2.0%;Uu和Mh混合阳性58例,占支原体阳性的13.6%。Uu对四环素类敏感率均高于80.0%,对喹诺酮类敏感率均低于41.0%,对大环类脂类敏感率高低不一;Uu+Mh混合感染对四环素类敏感率均高于58.0%,对喹诺酮类敏感率均低于23.0%,对大环类脂类敏感率高低不一。结论支原体感染以Uu感染为主,Uu+Mh感染为次,药敏试验结果以四环素类敏感性为最高,以喹诺酮类敏感性为最低。临床医生应加强支原体培养及药敏试验,根据患者临床症状及药敏试验结果合理选用抗菌药物。

Objective To study the mycoplasma infection（solution thiourea mycoplasma Uu and people type mycoplasma Mh） and analyze drug resistance of the patients with non-gonococcal urethritis.Methods The mycoplasma kit produced by Zhuhai Dark Horse biological engineering company was used to detect Uu and Mh and to do the drug sensitive experiment of 12 kinds of antibiotics,and the results were statistically analyzed.Results 426 cases of mycoplasma were found out of 957 patients specimen,accounted for 44.5% of all.There were 360 positive samples of Uu,accounted for 84.4% of the mycoplasma positive samples.There were 8 positive samples of Mh,accounted for 2.0% of all the mycoplasma positive samples.There were 58 positive samples of Uu mixed with Mh,accounted for 13.6% of the mycoplasma positive samples.The sensitive rate of Uu to the tetracyclin class was higher than 80.0%,while sensitive rate to quinolone was lower than 41.0%,but sensitive rate to the Macrocycle class was changeable.The sensitive rate of Uu ＋ the Mh mixed infection to the tetracyclin class was higher than 58.0%,while sensitive rate to quinolone was lower than 23.0%,but sensitive rate to the Macrocycle class was changeable.Conclusion The Uu infection is the primary source of mycoplasma infection,and Uu ＋ Mh infection is the second most frequent source.Tetracyclin class sensitivity has the highest drug sensitivity,while quinolone has the lowest drug sensitivity.Clinician should improve the culturing of mycoplasma and the drug sensitivity experiment,and use proper antibiotics according to the clinical patient symptoms and results of drug sensitivity experiment.