抽动秽语综合征PET脑代谢显像的研究

Study of ^(18)F-fluorodeoxyglucose positron emission tomography images in the Tourette syndrome

目的:利用PET技术观察抽动秽语综合征(TS)患者脑功能异常的部位。方法:经临床确诊TS患者65例,利用^(18)氟-脱氧葡萄糖((18)~F-FDG)行PET脑显像,图像采集自动重建后,目视观察(18)~F-FDG在PET脑显像图像中的代谢分布。结果:65例TS患者中PET脑显像异常者61例(93.8%)。异常部位代谢分布表现为放射性分布减低。受累的部位以颞叶和顶叶居多,右侧颞叶受累30例(49%),左侧颞叶受累9例(14.7%);左侧顶叶受累28例(45.9%),右侧顶叶受累9例(14.7%)。受累部位为1处者24例(39.3%),2处及以上者38例(62.3%)。结论:大多数TS患者都存在脑功能障碍,且受累部位代谢分布均为放射性分布减低;PET对TS的诊断有一定帮助。

Objective： To observe the characteristics of cerebral blood flow by positive emission tomography （PET） in the patients with Tourette Syndrome （TS） and to localize the abnormal region of cerebral glucose metabolism. Methods： The brains of 65 patients with TS were scanned with PET after administration of ^18 F-fluorodeoxyglucose （^18 F-FDG）. The patient＇s images which were obtained through computer processing were analyzed in detail. Results： There were 61 abnormal PET images in the 65 patients, the positive rate was 93. 8%. Lowered distribution of radiation was found in abnormal region in form of hypometabolism. The predominant abnormal regions were frontal lobe [the rate of positive focus on the right side was 30 cases （49%） and on the left side 9 cases （ 14.7%） and parietal lobe [the positive focus on the left side was 45.9% （28 cases） and on the right side was 14.7%（9 cases） ]. The positive rate of multi-focus was 62.3% （38 cases）, and that of the single-focus was 39.3 （24 cases）. Conclusion： Cerebral dysfunction was found in most of the patients with TS. ^18 F-FDG PET is very useful in the diagnosis of TS, and decreased distribution of radio-active isotope in the diseased parts of the brain.