甲状腺乳头状癌与乳头状增生的免疫组化特征

Immunohistochemical Features of Papillary Thyroid Carcinoma and Papillary Thyroid Hyperplasia

目的探讨甲状腺良恶性乳头状病变组织中细胞角质蛋白19(CK19)、半乳凝素-3(Gal-3)、HBME-1的表达及其鉴别诊断价值。方法应用免疫组化S-P法检测CK19、Gal-3、HBME-1在46例甲状腺乳头状癌、30例结节性甲状腺肿伴乳头状增生、30例癌旁正常滤泡组织中的表达情况。结果 CK19、Gal-3、HBME-1在甲状腺乳头状癌组织中的阳性表达率分别为100.0%、95.6%和91.3%,远高于结节性甲状腺肿伴乳头状增生及癌旁正常滤泡组织中的表达,差异均有统计学意义(P<0.01)。结论 CK19、Gal-3、HBME-1在甲状腺乳头状癌组织中有很高的表达,对甲状腺乳头状癌与乳头状增生的鉴别诊断有一定价值。

Objective To study the expressions of cytokeratin 19（CK19）,galectin-3（Gal-3） and HBME-1 in benign and malignant papillary lesions of thyroid and their differential diagnosis value.Methods By immunohistochemical S-P method,the expressions of CK19,Gal-3 and HBME-1 were detected in 46 cases of papillary thyroid carcinoma tissues,30 cases of multinodular goiters with papillary hyperplasia tissues and 30 cases of adjacent normal follicular tissues.Results The positive rates of CK19,Gal-3 and HBME-1 in papillary thyroid carcinoma were 100.0%,95.6% and 91.3%,which were significantly higher than those of 30 cases of multinodular goiters with papillary hyperplasia tissues and 30 cases of adjacent normal follicular tissues（P0.01）.Conclusion CK19,Gal-3 and HBME-1 expressions are significantly high in papillary thyroid carcinoma,which have the certain application value in differential diagnoses of papillary carcinoma and papillary hyperplasia.