奥沙利铂联合三维适形放疗治疗老年晚期食管癌的临床观察

The Clinical Observation of Oxaliplatin Combined with Three Dimensional Conformal Radiation Therapy in the Treatment of the Elderly Patients with Advanced Esophageal Carcinoma

目的观察奥沙利铂联合三维适形放疗治疗老年晚期食管癌的疗效和毒副反应。方法 80例老年晚期食管癌随机分为两组,试验组给予奥沙利铂化疗和三维适形放疗,而对照组仅给予三维适形放疗。治疗结束后两组分别评价疗效和毒副反应。结果试验组有效率为90.0%,对照组为72.5%,差异有统计学意义(P<0.05)。试验组和对照组1、2、3年生存率分别为56.5%、31.5%、22.0%和48.5%、28.5%、18.0%,差异均无统计学意义(P>0.05)。两组毒副反应发生率均较低,且均为轻度,但试验组的神经毒性发生率较对照组高(P<0.05)。结论奥沙利铂联合三维适形放疗治疗老年晚期食管癌能明显提高近期疗效,且毒副反应可耐受。

Objective To observe the efficacy and toxicities of oxaliplatin combined with three dimensional conformal radiation therapy in the treatment of the elderly patients with advanced esophageal carcinoma.Methods All the 80 elderly patients with advanced esophageal carcinoma were randomly divided into two groups.The 40 patients in the trial group received oxaliplatin and three dimensional conformal radiation therapy;the 40 patients in the control group received three dimensional conformal radiation therapy.The efficacy and toxicities were evaluated after treatment.Results The response rate was 90.0% in the trial group,and was 72.5% in the control group（P0.05）.The 1-,2-and 3-year survival rates were 56.5%,31.5%,22.0% in the trial group,and were 48.5%,28.5%,18.0%in the control group（P0.05）.The incidences of common toxicities of the two groups were low,and the toxicities were light;but the incidence of neurotoxicity in the trial group was higher than that of the control group（P0.05）.Conclusion Oxaliplatin combined with three dimensional conformal radiation therapy can improve the short term efficacy of the elderly patients with advanced esophageal carcinoma,and its toxicities are tolerable.