37例胃肠道间质瘤预后因素分析

The Clinical Analyses of the Prognosis Factors of 37 Patients with Gastrointestinal Stromal Tumor

目的探讨影响胃肠道间质瘤（G IST）预后的因素。方法回顾性分析37例G IST患者的免疫组化检测结果及肿瘤大小、生长部位、核分裂数,手术的切除程度与其预后的关系。结果 G IST患者的病理切片中CD117、CD34的阳性表达率分别为97.3%和78.4%。肿瘤直径〉10 cm、5~10 cm者预后较≤5 cm者差（P〈0.05）;核分裂数〉5/50 HPF者预后较≤5/50 HPF者差（P〈0.05）;行姑息性切除者比行完全性切除者预后差（P〈0.05）。结论完全性切除肿瘤能明显改善G IST患者的预后,肿瘤直径大小和核分裂数是影响预后的因素。

Objective To investigate the prognostic factors of patients with gastrointestinal stromal tumor（GIST）.Methods The clinical data of 37 patients with GIST were reviewed retrospectively.The clinicopathologic diagnoses were determined by immunochemistry method.The relationships of the prognoses with tumor size,tumor location,mitotic counts and range of tumor resection were analyzed.Results The positive rates of CD117 and CD34 were 97.3% and 78.4% in the pathological sections of patients with GIST respectively.The patients with tumor size 10 cm and 5-10 cm,mitotic counts 5/50 HPF,incomplete resection had poorer outcome than those of tumor size ≤5 cm,mitotic counts ≤5/50 HPF,complete resection（P0.05）.Conclusion Complete resection can improve the prognosis of patients with GIST.Tumor size and tumor mitotic counts are the prognostic factors.