参芎葡萄糖注射液治疗急性脑梗死的临床疗效分析

Analysis of the therapeutic effect of Ligustrazine and Salvia Injection in the treatment of acute cerebral infarction

目的评估参芎葡萄糖注射液治疗急性脑梗死患者的临床疗效,并评价其用药安全性。方法 100例急性脑梗死患者随机分为治疗组和对照组,每组50例。治疗组在常规治疗的基础上加用参芎葡萄糖注射液;对照组在常规治疗的基础上加复方丹参注射液,治疗14d后,对2组治疗前后神经功能缺损评分、临床疗效、血液流变学指标及不良反应进行分析。结果 2组治疗后神经功能缺损评分较治疗前降低(P<0.05),但治疗组降低更明显(P<0.05);治疗组的有效率显著高于对照组(P<0.01)。治疗组治疗后血小板聚集率、红细胞压积、纤维蛋白原较治疗前改善(P<0.01或P<0.05);对照组血小板聚集率、红细胞压积较治疗前改善(P<0.05);治疗组的红细胞压积、纤维蛋白原较对照组改善更明显(P<0.05)。治疗组1例出现皮疹,对照组未出现明显不良反应。结论 参芎葡萄糖注射液治疗急性脑梗死疗效可靠,临床用药安全,值得推广使用。

Objective To evaluate the clinical therapeutic effect of Ligustrazine and Salvia Injection in the treatment of acute cerebral infarction,and evaluate the safety of this medication.Methods A total of 100 cases of patients with acute cerebral infarction were selected and randomly divided into treatment group and control group,with 50 patients in each group.The treatment group was administered with Ligustrazine and Salvia Injection on the basis of routine treatments,and the control group was administered with Salvia Injection on the basis of routine treatments,the two groups were treated for 14 days,then the NIHSS score,clinical effect,hemorheological parameters and adverse effect of the two groups were analyzed.Results The NIHSS after treatment was lower than that before treatment in the two groups （P0.05）,but the treatment group was much lower than that of the control group （P0.05）;the effective rate of treatment group was significantly higher than that of control group （P0.01）.The platelet aggregation,hematocrit and fibrinogen after treatment were obviously improved in the treatment group （P0.01 or P0.05）,the platelet aggregation and hematocrit after treatment were also improved in the control group （P0.05）;the hematocrit and fibrinogen showed a more significant improvement in the treatment group compared with those of control group （P0.05）.1 case occurred erythra in the treatment group,and on obvious adverse effect was observed in the control group.Conclusion Ligustrazine and Salvia Injection shows a reliable and safe therapeutic effect in the treatment of acute cerebral infarction,thus it is worthy of application in clinic.