成人哮喘急性发作时大剂量雾化吸入皮质激素与静脉注射皮质激素的疗效对比

The comparison of effects to acute adult asthma between high-dose inhaled corticosteroids and intravenous dripping corticosteroids

目的探讨成人哮喘急性发作时大剂量雾化吸入皮质激素与静脉注射皮质激素的疗效。方法 90例患者随机分为3组,均予吸入万托林(沙丁胺醇),静脉点滴二羟丙茶碱治疗。观察组(30例)吸入大剂量普米克令舒;对照一组(30例)静脉注射甲基强的松龙;对照二组(30例)静脉点滴地塞米松。结果比较治疗后2小时症状和体征的变化、治疗3天时FEV1占预计值分数以及患者的平均住院时间,观察组与对照一组比较差异无显著统计学意义(P>0.05),与对照二组比较差异有显著的统计学意义(P<0.05)。结论对哮喘急性发作患者,在吸入支气管扩张剂的基础上吸入大剂量普米克令舒,能明显改善病情、提高肺功能及缩短住院天数,与静脉注射甲基强的松龙的效果相近,优于静脉点滴地塞米松。

Objective To discuss the curative effect of the acute adult asthma between high-dose inhaled corticosteroids and intravenous dripping corticosteroids.Methods 90 patients were divided into three groups randomly,all of them were inhaled Salbutamol Sulfate Respirator Solution and transfused diprophylline at first.Patients who in observation group（n = 30） inhaled high-dose pulmicort respules,in contrast group 1 intravenousdripped methylprednidolone;contrast group 2（n = 30） intravenousdripped desamethasone.Results There is no significant difference of 2 hours＇symptom and signs between observing group and contrast group 1（P 0.05）,but when compare to the contrast group 2,the difference is notable（P 0.05）.The same thing happened in the 3 days lung function（FEV1%） and the average time of hospital.Conclusion In the acute episode period of adult Asthma,inhaling pulmicort respules with bronchus expansion drug can relieve patient＇s condition and Shorten course of treatment,and can get a similar effects to intravenous dripping methylprednidolone.